Missionary work among the Aymara people of South America began in 1930 and has been strongly sustained since that time. Bolivia Yearly Meeting was established in 1975, and Peru Yearly Meeting was established in 1997. Northwest Yearly Meeting supplies assistance, particularly in education. The Yearly Meeting, through the Evangelical Friends International, also supports ministry in Mexico City, the Philippines, Rwanda, Taiwan, Burundi, and India; and has an interest in the Christian University of Bolivia and the Navajo people of Southwestern United States.

Northwest Yearly Meeting outreaches also includes social programs. In faithfulness to the peace testimony many young persons have engaged in relief work as an alternative to military service. Members often serve with agencies devoted to the alleviation of economic and cultural disparity in America or abroad. Inner-city ministries, peacemaking activities, and economic assistance to the needy receive local and Yearly Meeting direction. Yearly Meeting concern fostered construction of Friendsview Manor, a retirement home.

Interest in education is evidenced by the establishment at Newberg, Oregon, of Pacific Academy in 1885 and Pacific College in 1891 (renamed George Fox College in 1949). In 1996 with the merger of George Fox College and Western Evangelical Seminary, the college reached university status and thus became George Fox University. Greenleaf Academy in Idaho has been maintained by area Friends since 1908. These schools have contributed significantly to Quaker and Christian leadership in the Northwest and throughout the world. Recently several local churches have included schools and day-care centers in their ministry. The Yearly Meeting since 1918 has supported programs of camping and now has several conference centers. These presently include Twin Rocks on the Oregon coast, Quaker Hill and Twin Lakes in central and north Idaho, and Quaker Cove on the Puget Sound. Tilikum, a retreat center and day camp near Newberg, was established in 1970 as the result of a gift of property. It is an agency of George Fox University. These programs are widely used by the churches.

In its various missionary, educational, and outreach ministries, Northwest Yearly Meeting continues in the Christian tradition of Friends. Its interests and strengths vary from time to time. Sometimes the Yearly Meeting has misdirected its energies and misplaced its priorities; however, restoration to wholeness has also occurred, accompanied by unity and joy in the Lord.